BOX-BEHNKEN DESIGN OPTIMIZATION OF SALICYLIC ACID LOADED LIPOSOMAL GEL FORMULATION FOR TREATMENT OF FOOT CORN

Objective: The present research is aimed to design and optimize a liposomal gel formulation of salicylic acid (SA) for enhanced drug permeation, higher skin retention, sustained release delivery reduced side effects in the effective treatment foot corn. Methods: Formulation designing optimization SA-loaded liposomes was done by box-Behnken experimental using three-factor, three-level approach. Phospholipid content, cholesterol content were selected as independent variables; while critical quality attributes (CQAs) like particle size, PDI, zeta potential, entrapment efficiency cumulative % considered response variables. prepared ethanol injection method characterized desired CQAs. Finally, topical developed evaluated homogeneity, spreadability, vitro release, kinetics, ex-vivo permeation retention properties. Results: found be 261.2 nm, 0.28, 0.7 mV, 57.53% 99.57%, respectively. Developed exhibited profile (64.48% over 360 min) following Higuchi model kinetics. showed almost 2-fold (i.e., 26.50%) more than 10.90%) on porcine ear compared plain gel. Conclusion: possessed all studies confirmed suitability application